Tauromustine is an orally active nitrosourea anticancer agent. Tauromustine has an alkylation effect and can damage the DNA function. Tauromustine has a high therapeutic index, especially in the study of Walker 256 rat sarcoma. It is also active against melanoma, breast cancer , pleural mesothelioma and ovarian cancer . Tauromustine is mainly metabolized in the liver, but some of its metabolites also have cytotoxicity.
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