NSC666715

Overview

NSC666715 is a DNA polymerase β ( Pol-β ) inhibitor. NSC666715 directly and specifically interacts with Pol-β , interferes with its binding to damaged DNA , blocks its dRP lyase activity, and inhibits Pol-β -mediated SN- and LP-BER . NSC666715 induces AP site accumulation and S-phase cell cycle arrest, and triggers senescence and apoptosis ( apoptosis ) via the p53 / p21 pathway in colorectal cancer cells. NSC666715 enhances TMZ ( HY-17364 )-induced DNA damage, senescence and apoptosis , and potentiates the cytotoxicity of TMZ. NSC666715 inhibits tumor growth in colon cancer xenograft models. NSC666715 can be used in research related to colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PARP | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-120105
• CAS No.: 170747-33-8
• Molecular Formula: C15H13Cl2N5O2S2
• Molecular Weight: 430.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source