PD98059

Overview

PD98059 is a potent and selective MEK inhibitor with an IC 50 of 5 µM. PD98059 binds to the inactive form of MEK , thereby preventing the activation of MEK1 ( IC 50 of 2-7 µM) and MEK2 ( IC 50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) , and suppresses TCDD binding ( IC 50 of 4 μM) and AHR transformation ( IC 50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Pain | Products > Disease Areas > Obesity | Products > Disease Areas > Lung Fibrosis | Products > Disease Areas > Rheumatoid Arthritis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MEK | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Aryl Hydrocarbon Receptor | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-12028
• CAS No.: 167869-21-8
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.28
• Purity: 99.27%
• Storage: 4°C, protect from light * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)
• Solubility: 2.08 mg/mL (7.78 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source