T-1101 tosylate

Overview

T-1101 tosylate (TAI-95 tosylate) is the tosylate salt form of T-1101 ( HY-120356 ). T-1101 tosylate is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1) . T-1101 tosylate blocks the interaction between Hec1 and NEK2 , exhibits cytotoxicity in human liver cancer cells with GI 50 of 15-70 nM. T-1101 tosylate induces apoptosis in Huh-7. T-1101 tosylate exhibits antitumor efficacy in mouse models.

Application

Products | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NEKs | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-120356A
• CAS No.: 2250404-95-4
• Molecular Formula: C31H31N5O6S3
• Molecular Weight: 665.80
• Purity: 98.91%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (3.12 mM); Clear solution
• Availability: In-stock

Source

Original product source