Volasertib

Overview

Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 ( PLK1 ) inhibitor with an IC 50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC 50 s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis . Volasertib, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-12137
• CAS No.: 755038-65-4
• Molecular Formula: C34H50N8O3
• Molecular Weight: 618.81
• Purity: 99.97%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.08 mg/mL (3.36 mM); Clear solution
• Availability: In-stock

Source

Original product source