LT175

Overview

LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ (hPPARα: EC 50 =0.22 μm; mPPARα: EC 50 =0.26 μm; hPPARγ: EC 50 =0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties.

Application

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Product Information

• Catalog No.: HY-121900
• CAS No.: 862901-87-9
• Molecular Formula: C21H18O3
• Molecular Weight: 318.37
• Purity: 99.46%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (7.85 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source