ML309

Overview

ML309 is a highly selective and potent inhibitor of the R132H mutant isocitrate dehydrogenase 1 ( IDH1 R132H ), with an IC 50 of 96 nM. ML309 is a competitive inhibitor of α-KG , with a K i value of 156 nM, and its inhibitory activity against the wild-type IDH1 is greater than 35 μM. ML309 effectively reduces the production of the tumor metabolite 2-HG in U87MG cells. ML309 can be used as a chemical probe to study the role of the mutant IDH1 in cancer .

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Isocitrate Dehydrogenase (IDH)

Product Information

• Catalog No.: HY-121916
• CAS No.: 1355446-05-7
• Molecular Formula: C29H29FN4O2
• Molecular Weight: 484.56
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source