UMK57

Overview

UMK57 is a MCAK activator and kinetochore-microtubule destabilizer . UMK57 enhances MCAK -dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation . UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Mitosis | Products > Signaling Pathways > Kinesin | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > Aurora Kinase

Product Information

• Catalog No.: HY-122236
• CAS No.: 342595-74-8
• Molecular Formula: C17H17N3S
• Molecular Weight: 295.40
• Purity: 99.51%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source