PVZB1194

Overview

PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC 50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio ( IC 50 : 5.5 μM). PVZB1194 can be used in the study of tumors.

Application

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Product Information

• Catalog No.: HY-122247
• CAS No.: 1141768-04-8
• Molecular Formula: C13H9F4NO2S
• Molecular Weight: 319.27
• Purity: 99.64%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source