IWR-1

Overview

IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin ( IC 50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling , namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis.

Application

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Product Information

• Catalog No.: HY-12238
• CAS No.: 1127442-82-3
• Molecular Formula: C25H19N3O3
• Molecular Weight: 409.44
• Purity: 99.60%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution
• Availability: In-stock

Source

Original product source