HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase ( MELK ) inhibitor, with an IC 50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3 , RIPK2 , DYRK3 , smMLCK and CLK2 . HTH-01-091 can be uesd for breast cancer research.
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