VS-II-173

Overview

VS-II-173 is a pan-Pim kinase inhibitor with IC 50 values ​​of 0.07 μM and 0.02 μM for Pim1 and Pim3 , respectively, and a residual activity of 46% for Pim2 at 1 μM. VS-II-173 also inhibits kinases such as HIPK2 , PRK2 , RSK1 , DYRK1a and AMPK α1 , selectively inhibiting acute myeloid leukemia (AML) cells with significantly lower toxicity to non-malignant cells ( EC 50 > 30 μM). VS-II-173 weakens the phosphorylation of substrates such as Stat5 (Y694) , MDM2 (S166) , Bad (S112) , and 4E-BP1 (T37/46) by inhibiting Pim kinase-mediated signaling pathways, blocking pro-survival signals in AML cells and inducing apoptosis . VS-II-173 synergistically enhances anti-AML activity when combined with Daunorubicin ( HY-13062A ). VS-II-173 can be used in AML research, especially for AML with FLT3-ITD mutations and NPM1 mutations .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > DYRK | Products > Signaling Pathways > STAT | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Pim | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-122670
• CAS No.: 1627962-21-3
• Molecular Formula: C14H8N4O2
• Molecular Weight: 264.24
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source