PNU-292137

Overview

PNU-292137 is an orally active, potent CDK2 inhibitor with IC 50 s of 37 nM and 92 nM for CDK2/cyclin A and CDK2/cyclin E, respectively. PNU-292137 makes interactions with the hydrophobic pocket at the back of the CDK2 ATP pocket. PNU-292137 efficiently inhibits tumor cell proliferation in human colon and prostate tumor cell lines. PNU-292137 exhibits antitumor activity (TGI>50%) in a mouse xenograft model.

Application

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Product Information

• Catalog No.: HY-123045
• CAS No.: 326823-27-2
• Molecular Formula: C18H17N3O
• Molecular Weight: 291.35
• Purity: 99.95%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (8.58 mM); Clear solution
• Availability: In-stock

Source

Original product source