20(S)-Hydroxycholesterol

Overview

20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened ( Smo ) of the Hedgehog pathway with an EC 50 of ~30 μM ( Hedgehog ). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin ( HY-17502 ) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis.

Application

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Product Information

• Catalog No.: HY-12316
• CAS No.: 516-72-3
• Molecular Formula: C27H46O2
• Molecular Weight: 402.65
• Purity: 99.63%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 1.25 mg/mL (3.10 mM); Clear solution
• Availability: In-stock

Source

Original product source