GSK2194069

Overview

GSK2194069 is a potent inhibitor of β-ketoyl reductase ( KR ) of fatty acid synthase ( FASN ), with an IC 50 value of 7.7 nM. GSK2194069 shows specifically inhibitory effect on FAS expressing cancer cells, by acting potent efficacy on acetoacetyl-CoA, NADPH with IC 50 or K i values of 4.8 nM and 5.6 nM, respectively.

Application

Products | Products > Disease Areas > Obesity | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Fatty Acid Synthase (FASN)

Product Information

• Catalog No.: HY-12325
• CAS No.: 1332331-08-4
• Molecular Formula: C25H24N4O3
• Molecular Weight: 428.48
• Purity: 99.80%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution
• Availability: In-stock

Source

Original product source