PKUMDL-WQ-2201

Overview

PKUMDL-WQ-2201 is a PHGDH non-NAD+-competing allosteric inhibitor ( IC 50 =35.7 μM). PKUMDL-WQ-2201 also inhibits PHGDH mutants with IC 50 s of 69 μM (T59A) and >300 μM (T56AK57A), respectively. PKUMDL-WQ-2201 inhibits de novo serine synthesis in cancer cells, and reduces tumor growth.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Phosphoglycerate Dehydrogenase (PHGDH)

Product Information

• Catalog No.: HY-123418
• CAS No.: 592474-91-4
• Molecular Formula: C15H14ClN3O3S
• Molecular Weight: 351.81
• Purity: 98.45%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source