ML216

Overview

ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC 50 s of 2.98 μM and 0.97 μM for BLM full-length and BLM 636-1298 , respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a K i of 1.76 μM. Antitumor avtivity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-12342
• CAS No.: 1430213-30-1
• Molecular Formula: C15H9F4N5OS
• Molecular Weight: 383.32
• Purity: 99.89%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 2 mg/mL (5.22 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source