L-783277

Overview

L-783277 (Compound 4) is a MEK inhibitor ( IC 50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3 , FLT1/3/4 , MEK1/2 , KDR, and PDGFRα , but has low selectivity for the kinase community. L-783277 inhibits viability ( IC 50 = 22 mM) and cell proliferation ( IC 50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > MEK | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > FLT3 | Products > Signaling Pathways > PDGFR

Product Information

• Catalog No.: HY-123586
• CAS No.: 791807-02-8
• Molecular Formula: C19H24O7
• Molecular Weight: 364.39
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source