CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a K D of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ , and its downstream target the glucose transporter GLUT4 . CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity.
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