BTYNB

Overview

BTYNB is a structure-specific nucleic acid binder and IGF2BP1 inhibitor (with an IC 50 of 5 μM against hBTYNB ). BTYNB disrupts the IGF2BP1-RNA interaction and blocks its binding to oncogenic mRNAs such as c-Myc , MDM2 , PD-L1 . BTYNB completely blocks the INHBA-Smad2/3 pathway, disrupts the MYCN/IGF2BP1 loop, and thereby induces apoptosis and cell cycle arrest, effectively inhibiting the proliferation and survival of cancer cells. In addition, BTYNB acts as an immune activator and tumor microenvironment modulator, enhances T cell-mediated tumor killing, and produces significant synergistic effects with inhibitors of PD-1 , BRD and BIRC5 . BTYNB can be used in relevant research on various malignant tumors including ovarian cancer , neuroblastoma, leukemia and melanoma.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Melanoma | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Metastatic Melanoma | Products > Disease Areas > Squamous Cell Carcinoma | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > IGF-1R | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > TGF-beta/Smad

Product Information

• Catalog No.: HY-124447
• CAS No.: 304456-62-0
• Molecular Formula: C12H9BrN2OS
• Molecular Weight: 309.18
• Purity: 98.0%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (8.09 mM); Clear solution
• Availability: In-stock

Source

Original product source