CMLD-2

Overview

CMLD-2, an inhibitor of HuR-ARE interaction , competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs ( K i =350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R ( HuR ) is an RNA binding protein, can regulate target mRNAs stability and translation.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HuR

Product Information

• Catalog No.: HY-124828
• CAS No.: 958843-91-9
• Molecular Formula: C31H31NO6
• Molecular Weight: 513.58
• Purity: 98.66%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution
• Availability: In-stock

Source

Original product source