Nrf2 activator-10

Overview

Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element ( ARE ) ( EC 50 is 2.7 μM) and an activator for Nrf2 . Nrf2 activator-10 modifies Keap1 , blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H 2 O 2 -induced apoptosis .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-124834
• CAS No.: 75483-04-4
• Molecular Formula: C13H12ClNO3
• Molecular Weight: 265.69
• Purity: 98.65%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source