PHA-680626

Overview

PHA-680626 is an effective inhibitor of the interaction between Aurora-A and N-Myc . PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl , and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib ( HY-15463 )-resistant chronic myeloid leukemia cell lines and primary CD34+ cells.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Aurora Kinase | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > Bcr-Abl | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-125090
• CAS No.: 398493-74-8
• Molecular Formula: C23H26N6O2S
• Molecular Weight: 450.56
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source