AZ12253801

Overview

AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ∼10-fold selectivity over the insulin receptor . AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R ) with an IC 50 of 17 nmol/L. The IC 50 for epidermal growth factor receptor ( EGFR )–driven proliferation is 440 nmol/L. Anti-tumor activity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > IGF-1R

Product Information

• Catalog No.: HY-125102
• CAS No.: 851432-37-6
• Molecular Formula: C21H22N8O
• Molecular Weight: 402.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source