OSU-53

Overview

OSU-53 is an orally active AMPK activator (EC 50 : 0.3 μM) and a direct mTOR inhibitor. OSU-53 induces autophagy and increases conversion of LC3 I to LC3 II. OSU-53 also modulates energy homeostasis by suppressing fatty acid biosynthesis and shifting the metabolism to oxidation by up-regulating the expression of PGC1α and NRF-1. OSU-53 has antitumor activity in various tumor models, such as breast cancer and thyroid cancer .

Application

Products | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Atg8/LC3

Product Information

• Catalog No.: HY-125535
• CAS No.: 1290069-19-0
• Molecular Formula: C25H24F3N3O6S2
• Molecular Weight: 583.60
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source