SKF-96365

Overview

SKF-96365 is a TRPC channel antagonist and store-operated calcium entry ( SOCE ) inhibitor. SKF-96365 reduces calcium ion influx by inhibiting the activity and expression of TRPC6 , STIM1 and Orai1 . SKF-96365 inhibits voltage-gated sodium current (cardiac I Na /NaV1.5 ) and slows myocardial conduction. SKF-96365 inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 induces G 2 /M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis . SKF-96365 inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 is applicable to research related to allergic rhinitis, colorectal cancer , Parkinson's disease, persistent spontaneous nociception and hyperalgesia.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Allergy | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Na+/Ca2+ Exchanger | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > CRAC Channel | Products > Signaling Pathways > TRP Channel | Products > Signaling Pathways > CaMK

Product Information

• Catalog No.: HY-125942
• CAS No.: 162849-90-3
• Molecular Formula: C22H26N2O3
• Molecular Weight: 366.45
• Purity: 99.97%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (13.64 mM); Clear solution
• Availability: In-stock

Source

Original product source