(±)-ML 209

Overview

(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC 50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC 50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4 + T cells into other lineages, including Th1 and regulatory T cells.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > ROR

Product Information

• Catalog No.: HY-126037
• CAS No.: 1334526-14-5
• Molecular Formula: C25H31NO6
• Molecular Weight: 441.52
• Purity: 98.14%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution
• Availability: In-stock

Source

Original product source