J22352

Overview

J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC 50 value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1 .

Application

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Product Information

• Catalog No.: HY-126147
• CAS No.: 2252395-44-9
• Molecular Formula: C24H21N3O4
• Molecular Weight: 415.44
• Purity: 99.04%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (5.01 mM); Clear solution
• Availability: In-stock

Source

Original product source