JH-RE-06

Overview

JH-RE-06, a potent REV1-REV7 interface inhibitor ( IC 50 =0.78 μM; K d =0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-126214
• CAS No.: 1361227-90-8
• Molecular Formula: C20H16Cl3N3O4
• Molecular Weight: 468.72
• Purity: 99.87%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.33 mM); Clear solution
• Availability: In-stock

Source

Original product source