(R)-BI-2852

Overview

(R)-BI-2852 is the isomer of BI-2852 ( HY-126247 ), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

Application

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Product Information

• Catalog No.: HY-126247B
• CAS No.: 2375482-49-6
• Molecular Formula: C31H28N6O2
• Molecular Weight: 516.59
• Purity: 97.32%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Availability: In-stock

Source

Original product source