BI-4924

Overview

BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase ( PHGDH ) inhibitor ( IC 50 =3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC 50 of 2200 nM at 72 h.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Phosphoglycerate Dehydrogenase (PHGDH)

Product Information

• Catalog No.: HY-126254
• CAS No.: 2244452-09-1
• Molecular Formula: C21H20Cl2N2O6S
• Molecular Weight: 499.36
• Purity: 99.55%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (4.17 mM); Clear solution
• Availability: In-stock

Source

Original product source