AMG PERK 44

Overview

AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC 50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC 50 =7300 nM) and B-Raf (IC 50 >1000 nM), respectively. AMG PERK 44 induces autophagy .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PERK | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-12661A
• CAS No.: 1883548-84-2
• Molecular Formula: C34H29ClN4O2
• Molecular Weight: 561.07
• Purity: 99.67%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (3.71 mM); Clear solution
• Availability: In-stock

Source

Original product source