Levoleucovorin (Levofolinic acid; Levofolene) is the pharmacologically and orally active levoisomer of Folinic acid ( HY-17556 ), a synthetic folate analogue. Levoleucovorin can inhibit LOXL2 with an IC 50 of 68.81 μM. Levoleucovorin can inhibit cancer cells proliferation, migration and induce apoptosis . Levoleucovorin can be used as a rescue agent for high-dose Methotrexate ( HY-14519 ). Levoleucovorin can reduce the frequency of embryonic malformations. Levoleucovorin can be used for the research of can and endocrinology , such as breast cancer and osteosarcoma.
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