LRH-1 antagonist-1 (Compound 3d2) is a LRH-1 antagonist with a K d of 1.8 μM. LRH-1 antagonist-1 inhibits the transcriptional activity of LRH-1 and reduces the expression of G0S2. LRH-1 antagonist-1 inhibits the proliferation of LRH-1-positive cancer cells. LRH-1 antagonist-1 can be used for research on pancreatic cancer , colon cancer and breast cancer .
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