COH34

Overview

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Poly(ADP-ribose) Glycohydrolase (PARG)

Product Information

• Catalog No.: HY-128760
• CAS No.: 906439-72-3
• Molecular Formula: C18H15NOS
• Molecular Weight: 293.38
• Purity: 99.97%
• Storage: Powder -20°C, 3 years , 4°C, 2 years * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 1.67 mg/mL (5.69 mM); Clear solution
• Availability: In-stock

Source

Original product source