(S,R)-GSK321

Overview

(S,R)-GSK321 is the (S,R)-enantiomer of GSK321 ( HY-18948 ). GSK321 is a potent, selective mutant IDH1 inhibitor with IC 50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1 , respectively, and >100-fold selectivity over IDH2 . GSK321 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321 can be used for research of acute myeloid leukemia (AML) and other cancers.

Application

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Product Information

• Catalog No.: HY-128888B
• CAS No.: 1816272-18-0
• Molecular Formula: C28H28FN5O3
• Molecular Weight: 501.55
• Purity: 98.62%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source