SLR080811

Overview

SLR080811 is a guanidine-based selective sphingosine kinase 2 ( SphK2 ) inhibitor with a K i of 1.3 μM, exhibiting ~10-fold selectivity over SphK1 ( K i = 12 μM). SLR080811 reduces sphingosine 1-phosphate (S1P) levels in vitro, but drives a SphK1-dependent increase in S1P in mice. SLR080811 can be used for cancers and fibrosis research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > SphK

Product Information

• Catalog No.: HY-12896
• CAS No.: 1449765-65-4
• Molecular Formula: C21H31N5O
• Molecular Weight: 369.50
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source