(Z)-S49076 hydrochloride

Overview

(Z)-S49076 hydrochloride is an orally active inhibitor of MET and AXL that blocks the downstream signaling of these receptors both in vitro and in vivo , inhibiting the proliferation and migration of tumor cells and suppressing tumor growth in xenograft models. (Z)-S49076 hydrochloride is capable of overcoming the resistance to epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors (TKIs) due to MET amplification in Erlotinib ( HY-50896 )-resistant cell lines both in vitro and in vivo . (Z)-S49076 hydrochloride can be used for research in non-small cell lung cancer (NSCLC).

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Signaling Pathways > TAM Receptor

Product Information

• Catalog No.: HY-12965B
• CAS No.: 1265965-19-2
• Molecular Formula: C22H23ClN4O4S
• Molecular Weight: 474.96
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source