Adagrasib

Overview

Adagrasib (MRTX849) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. Adagrasib covalently binds to KRAS G12C at the cysteine at residue 12, locks the protein in its inactive GDP-bound conformation, and inhibits KRAS-dependent signal transduction.

Application

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Product Information

• Catalog No.: HY-130149
• CAS No.: 2326521-71-3
• Molecular Formula: C32H35ClFN7O2
• Molecular Weight: 604.12
• Purity: 99.96%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.62 mg/mL (4.34 mM); Clear solution
• Availability: In-stock

Source

Original product source