NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC 50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1 , respectively. NVS-PAK1-C is also against dephosphorylated PAK2 ( IC 50 =270 nM) and phosphorylated PAK2 ( IC 50 =720 nM).
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