MK2-IN-3

Overview

MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2) , with an IC 50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2 , MNK1 , p38a (IC 50 s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2 , JNK2 , IKK2 (IC 50 s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MAPKAPK2 (MK2)

Product Information

• Catalog No.: HY-131249
• CAS No.: 724711-21-1
• Molecular Formula: C21H16N4O
• Molecular Weight: 340.38
• Purity: 99.15%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source