PDE5-IN-3

Overview

PDE5-IN-3 (compound 11j) is a potent PDE5 inhibitor with an IC 50 of 1.57 nM. PDE5-IN-3 shows moderate EGFR inhibition with IC 50 of 5.827 µM. PDE5-IN-3 significantly inhibits the Wnt/β-catenin pathway (IC 50 =1286.96 ng/mL). PDE5-IN-3 induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells. PDE5-IN-3 has strong antitumor activity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > Wnt

Product Information

• Catalog No.: HY-131710
• CAS No.: 2538149-57-2
• Molecular Formula: C21H14BrN5O2
• Molecular Weight: 448.27
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source