DS44960156

Overview

DS44960156 is a selective MTHFD2 inhibitor with moderate to low blood-brain barrier penetration ( IC 50 =1.6 μM, K i =1.23 μM). DS44960156 specifically binds to the active site of MTHFD2 , disrupts redox homeostasis and blocks serine-mediated one-carbon metabolism, thereby increasing the NAD + /NADH ratio and ROS levels. DS44960156 not only effectively inhibits the proliferation of glioma cells, but also enhances the sensitivity of cells to glutamine starvation-induced death. DS44960156 binds to plasma proteins, shows no mutagenicity, carcinogenicity or acute oral toxicity, and serves as a research agent for glioblastoma multiforme and other cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Glioma | Products > Disease Areas > Glioblastoma | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Product Information

• Catalog No.: HY-131943
• CAS No.: 2361327-08-2
• Molecular Formula: C20H15NO5
• Molecular Weight: 349.34
• Purity: 99.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution
• Availability: In-stock

Source

Original product source