(1E)-CFI-400437 dihydrochloride

Overview

(1E)-CFI-400437 dihydrochloride is a potent PLK4 ( IC 50 = 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC 50 s of 0.37, 0.21, 0.48, and 0.18 μM, respectively. Antiproliferative activity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Polo-like Kinase (PLK)

Product Information

• Catalog No.: HY-132135
• CAS No.: 1247000-76-5
• Molecular Formula: C29H30Cl2N6O2
• Molecular Weight: 565.49
• Purity: 98.03%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source