FD223

Overview

FD223 is a potent and selective phosphoinositide 3-kinase delta ( PI3Kδ ) inhibitor. FD223 displays high potency ( IC 50 =1 nM) and good selectivity over other isoforms (IC 50 s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ). FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML.

Application

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Product Information

• Catalog No.: HY-132231
• CAS No.: 2050524-24-6
• Molecular Formula: C17H12ClN5O2S
• Molecular Weight: 385.83
• Purity: 98.05%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.48 mM); Clear solution
• Availability: In-stock

Source

Original product source