AZD4877

Overview

AZD4877 is another isostere to Ispinesib ( HY-50759 )and also a kinesin spindle protein ( Eg5 ) inhibitor with IC 50 of 2 nM.AZD4877 arrests cell mitosis , leads to the formation of the monopolar spindle phenotype and induces apoptosis . AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pain | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Kinesin | Products > Signaling Pathways > Mitosis | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-13224
• CAS No.: 758722-49-5
• Molecular Formula: C28H33N5O2S
• Molecular Weight: 503.66
• Purity: 99.49%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (9.93 mM); Clear solution
• Availability: In-stock

Source

Original product source