Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 ( Mcl-1 ) protein inhibitor with a K d of 0.23 nM and a K i of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members ( Bcl-2 , Bcl2A1, Bcl-xL , and Bcl-w , K d >10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent.
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