Taladegib

Overview

Taladegib is a Smoothened ( SMO ) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC 50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC 50 of 7.6 nM in CGNP cell proliferation assays. Taladegib binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli -dependent transcription. Taladegib can be used in studies of Hedgehog pathway-related cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > Smo | Products > Signaling Pathways > Gli

Product Information

• Catalog No.: HY-13242
• CAS No.: 1258861-20-9
• Molecular Formula: C26H24F4N6O
• Molecular Weight: 512.50
• Purity: 99.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution
• Availability: In-stock

Source

Original product source