BS-181

Overview

BS-181 is a potent and selective CDK7 inhibitor ( IC 50 =21 nM) than Seliciclib ( HY-30237 ). BS-181 is also against CDK2 , CDK5 and CDK9 with IC 50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1 , 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC 50 =11.5 μM-37.3 μM) and induces cell apoptosis . BS-181 has the potential for the research of cancer therapy.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-13266
• CAS No.: 1092443-52-1
• Molecular Formula: C22H32N6
• Molecular Weight: 380.53
• Purity: 95.47%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 3 mg/mL (7.88 mM); Clear solution
• Availability: In-stock

Source

Original product source