Tunlametinib

Overview

Tunlametinib is a highly selective, orally active MEK1/2 inhibitor ( IC 50 =1.9 nM, MEK1 ). Tunlametinib blocks the RAS-RAF-MEK-ERK signaling pathway, arrests tumor cell cycle and promotes apoptosis . Tunlametinib potently inhibits the proliferation of RAS/RAF mutant cancer cells (such as BRAF V600E, KRAS G12C mutant cells). Tunlametinib shows synergistic anti-tumor effects with BRAF/KRASG12C/SHP2 inhibitors, Docetaxel ( HY-B0011 ). Tunlametinib can be used to study targeted therapy for RAS/RAF mutation-driven malignancies (such as melanoma, colorectal cancer , and non-small cell lung cancer ).

Application

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Product Information

• Catalog No.: HY-132844
• CAS No.: 1801756-06-8
• Molecular Formula: C16H12F2IN3O3S
• Molecular Weight: 491.25
• Purity: 99.53%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (10.18 mM); Clear solution
• Availability: In-stock

Source

Original product source